Publications
Dhar A, Balaji NKP, Mullick S#, Dey S#, Ghosh A, Nair D, Gadadhar S, Palani S. (2025). IntAct-U-ExM: Ultrastructure Expansion microscopy of actin networks via an internally-tagged actin. bioRxiv. 654030. https://doi.org/10.1101/2025.05.14.654030
Mercey O, Gadadhar S, Magiera MM, Lebrun L, Kostic C, Moulin A, Arsenijevic Y, Janke C, Guichard P, Hamel V. (2024). Glutamylation imbalance impairs the molecular architecture of the photoreceptor cilium. EMBO J. 43(24):6679-6704. https://doi.org/10.1038/s44318-024-00284-1
Gadadhar, Sˆ., Hirschmugl, T., & Janke, Cˆ. (2022). The tubulin code in mammalian sperm development and function. Seminars in Cell and Developmental Biology. 137:26-37. https://doi.org/10.1016/j.semcdb.2021.12.003
ˆco-corresponding author
Gadadhar, Sˆ., Viar, G. A., Hansen, J. N., Gong, A., Kostarev, A., Ialy-Radio, C., Leboucher, S., Whitfield, M., Ziyyat, A., Touré, A., Alvarez, Lˆ., Pigino, Gˆ., & Janke, Cˆ. (2021). Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. Science, 371(6525). https://doi.org/10.1126/science.abd4914
ˆco-corresponding author, highlighted on the cover of Science
Bodakuntla, S., Yuan, X., Genova, M., Gadadhar, S., Leboucher, S., Birling, M.-C., Klein, D., Martini, R., Janke, C., & Magiera, M. M. (2021). Distinct roles of α- and β-tubulin polyglutamylation in controlling axonal transport and in neurodegeneration. EMBO Journal, 40(17). https://doi.org/10.15252/embj.2021108498
Giordano, T*., Gadadhar, S*., Bodakuntla, S., Straub, J., Leboucher, S., Martinez, G., Chemlali, W., Bosc, C., Andrieux, A., Bieche, I., Arnoult, C., Geimer, S., & Janke, C. (2019). Loss of the deglutamylase CCP5 perturbs multiple steps of spermatogenesis and leads to male infertility. Journal of Cell Science, 132(3). https://doi.org/10.1242/jcs.226951
*equal contribution
Magiera, M. M., Singh, P., Gadadhar, S., & Janke, C. (2018). Tubulin Posttranslational Modifications and Emerging Links to Human Disease. Cell, 173(6), 1323–1327. https://doi.org/10.1016/j.cell.2018.05.018
Gadadhar, S., Dadi, H., Bodakuntla, S., Schnitzler, A., Bièche, I., Rusconi, F., & Janke, C. (2017). Tubulin glycylation controls primary cilia length. Journal of Cell Biology, 216(9), 2701–2713. https://doi.org/10.1083/jcb.201612050
Gadadhar, S., Bodakuntla, S., Natarajan, K., & Janke, C. (2017). The tubulin code at a glance. Journal of Cell Science, 130(8), 1347–1353. https://doi.org/10.1242/jcs.199471
Natarajan, K., Gadadhar, S., Souphron, J., Magiera, M. M., & Janke, C. (2017). Molecular interactions between tubulin tails and glutamylases reveal determinants of glutamylation patterns. EMBO Reports, 18(6), 1013–1026. https://doi.org/10.15252/embr.201643751
Grau, M. B., Masson, C., Gadadhar, S., Rocha, C., Tort, O., Sousa, P. M., Vacher, S., Bieche, I., & Janke, C. (2017). Alterations in the balance of tubulin glycylation and glutamylation in photoreceptors leads to retinal degeneration. Journal of Cell Science, 130(5), 938–949. https://doi.org/10.1242/jcs.199091
Gadadhar, S., Bora, N., Tiwari, V., & Karande, A. A. (2014). Sequestration of the abrin A chain to the nucleus by BASP1 increases the resistance of cells to abrin toxicity. Biochemical Journal, 458(2), 375–385. https://doi.org/10.1042/bj20131110
Goswami, T. K., Gadadhar, S., Balaji, B., Gole, B., Karande, A. A., & Chakravarty, A. R. (2014). Ferrocenyl-l-amino acid copper(ii) complexes showing remarkable photo-induced anticancer activity in visible light. Dalton Transactions, 43(31), 11988–11999. https://doi.org/10.1039/c4dt01348d
Gadadhar, S., & Karande, A. A. (2013). Abrin Immunotoxin: Targeted Cytotoxicity and Intracellular Trafficking Pathway. PLoS ONE, 8(3). https://doi.org/10.1371/journal.pone.0058304
Goswami, T. K., Gadadhar, S., Karande, A. A., & Chakravarty, A. R. (2013). Photocytotoxic ferrocene-appended (l-tyrosine)copper(II) complexes of phenanthroline bases. Polyhedron, 52, 1287–1298. https://doi.org/10.1016/j.poly.2012.06.018
Goswami, T. K., Gadadhar, S., Gole, B., Karande, A. A., & Chakravarty, A. R. (2013). Photocytotoxicity of copper(II) complexes of curcumin and N-ferrocenylmethyl-l-amino acids. European Journal of Medicinal Chemistry, 63, 800–810. https://doi.org/10.1016/j.ejmech.2013.03.026
Goswami, T. K., Gadadhar, S., Roy, M., Nethaji, M., Karande, A. A., & Chakravarty, A. R. (2012). Ferrocene-conjugated copper(II) complexes of l -methionine and phenanthroline bases: Synthesis, structure, and photocytotoxic activity. Organometallics, 31(8), 3010–3021. https://doi.org/10.1021/om201102k
Maity, B., Gadadhar, S., Goswami, T. K., Karande, A. A., & Chakravarty, A. R. (2012). Photo-induced anticancer activity of polypyridyl platinum(II) complexes. European Journal of Medicinal Chemistry, 57, 250–258. https://doi.org/10.1016/j.ejmech.2012.09.025
Hussain, A., Gadadhar, S., Goswami, T. K., Karande, A. A., & Chakravarty, A. R. (2012). Photo-induced DNA cleavage activity and remarkable photocytotoxicity of lanthanide(iii) complexes of a polypyridyl ligand. Dalton Transactions, 41(3), 885–895. https://doi.org/10.1039/c1dt11400j
Hussain, A., Gadadhar, S., Goswami, T. K., Karande, A. A., & Chakravarty, A. R. (2012). Photoactivated DNA cleavage and anticancer activity of pyrenyl-terpyridine lanthanide complexes. European Journal of Medicinal Chemistry, 50, 319–331. https://doi.org/10.1016/j.ejmech.2012.02.011
Maity, B., Gadadhar, S., Goswami, T. K., Karande, A. A., & Chakravarty, A. R. (2011). Impact of metal on the DNA photocleavage activity and cytotoxicity of ferrocenyl terpyridine 3d metal complexes. Dalton Transactions, 40(44), 11904–11913. https://doi.org/10.1039/c1dt11102g
Bora, N., Gadadhar, S., & Karande, A. A. (2010). Signaling different pathways of cell death: Abrin induced programmed necrosis in U266B1 cells. International Journal of Biochemistry and Cell Biology, 42(12), 1993–2003. https://doi.org/10.1016/j.biocel.2010.08.012