Publications
Dhar A, Balaji NKP, Mullick S#, Dey S#, Ghosh A, Nair D, Gadadhar S, Palani S. (2025). IntAct-U-ExM: Ultrastructure Expansion microscopy of actin networks via an internally-tagged actin. bioRxiv. 654030. https://doi.org/10.1101/2025.05.14.654030
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Mercey O, Gadadhar S, Magiera MM, Lebrun L, Kostic C, Moulin A, Arsenijevic Y, Janke C, Guichard P, Hamel V. (2024). Glutamylation imbalance impairs the molecular architecture of the photoreceptor cilium. EMBO J. 43(24):6679-6704. https://doi.org/10.1038/s44318-024-00284-1
Gadadhar, Sˆ., Hirschmugl, T., & Janke, Cˆ. (2022). The tubulin code in mammalian sperm development and function. Seminars in Cell and Developmental Biology. 137:26-37. https://doi.org/10.1016/j.semcdb.2021.12.003
ˆco-corresponding author
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Gadadhar, Sˆ., Viar, G. A., Hansen, J. N., Gong, A., Kostarev, A., Ialy-Radio, C., Leboucher, S., Whitfield, M., Ziyyat, A., Touré, A., Alvarez, Lˆ., Pigino, Gˆ., & Janke, Cˆ. (2021). Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. Science, 371(6525). https://doi.org/10.1126/science.abd4914
ˆco-corresponding author, highlighted on the cover of Science
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Bodakuntla, S., Yuan, X., Genova, M., Gadadhar, S., Leboucher, S., Birling, M.-C., Klein, D., Martini, R., Janke, C., & Magiera, M. M. (2021). Distinct roles of α- and β-tubulin polyglutamylation in controlling axonal transport and in neurodegeneration. EMBO Journal, 40(17). https://doi.org/10.15252/embj.2021108498
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Giordano, T*., Gadadhar, S*., Bodakuntla, S., Straub, J., Leboucher, S., Martinez, G., Chemlali, W., Bosc, C., Andrieux, A., Bieche, I., Arnoult, C., Geimer, S., & Janke, C. (2019). Loss of the deglutamylase CCP5 perturbs multiple steps of spermatogenesis and leads to male infertility. Journal of Cell Science, 132(3). https://doi.org/10.1242/jcs.226951
*equal contribution
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Magiera, M. M., Singh, P., Gadadhar, S., & Janke, C. (2018). Tubulin Posttranslational Modifications and Emerging Links to Human Disease. Cell, 173(6), 1323–1327. https://doi.org/10.1016/j.cell.2018.05.018
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Gadadhar, S., Dadi, H., Bodakuntla, S., Schnitzler, A., Bièche, I., Rusconi, F., & Janke, C. (2017). Tubulin glycylation controls primary cilia length. Journal of Cell Biology, 216(9), 2701–2713. https://doi.org/10.1083/jcb.201612050
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Gadadhar, S., Bodakuntla, S., Natarajan, K., & Janke, C. (2017). The tubulin code at a glance. Journal of Cell Science, 130(8), 1347–1353. https://doi.org/10.1242/jcs.199471
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Natarajan, K., Gadadhar, S., Souphron, J., Magiera, M. M., & Janke, C. (2017). Molecular interactions between tubulin tails and glutamylases reveal determinants of glutamylation patterns. EMBO Reports, 18(6), 1013–1026. https://doi.org/10.15252/embr.201643751
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Grau, M. B., Masson, C., Gadadhar, S., Rocha, C., Tort, O., Sousa, P. M., Vacher, S., Bieche, I., & Janke, C. (2017). Alterations in the balance of tubulin glycylation and glutamylation in photoreceptors leads to retinal degeneration. Journal of Cell Science, 130(5), 938–949. https://doi.org/10.1242/jcs.199091
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Gadadhar, S., Bora, N., Tiwari, V., & Karande, A. A. (2014). Sequestration of the abrin A chain to the nucleus by BASP1 increases the resistance of cells to abrin toxicity. Biochemical Journal, 458(2), 375–385. https://doi.org/10.1042/bj20131110
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Goswami, T. K., Gadadhar, S., Balaji, B., Gole, B., Karande, A. A., & Chakravarty, A. R. (2014). Ferrocenyl-l-amino acid copper(ii) complexes showing remarkable photo-induced anticancer activity in visible light. Dalton Transactions, 43(31), 11988–11999. https://doi.org/10.1039/c4dt01348d
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Gadadhar, S., & Karande, A. A. (2013). Abrin Immunotoxin: Targeted Cytotoxicity and Intracellular Trafficking Pathway. PLoS ONE, 8(3). https://doi.org/10.1371/journal.pone.0058304
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Goswami, T. K., Gadadhar, S., Karande, A. A., & Chakravarty, A. R. (2013). Photocytotoxic ferrocene-appended (l-tyrosine)copper(II) complexes of phenanthroline bases. Polyhedron, 52, 1287–1298. https://doi.org/10.1016/j.poly.2012.06.018
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Goswami, T. K., Gadadhar, S., Gole, B., Karande, A. A., & Chakravarty, A. R. (2013). Photocytotoxicity of copper(II) complexes of curcumin and N-ferrocenylmethyl-l-amino acids. European Journal of Medicinal Chemistry, 63, 800–810. https://doi.org/10.1016/j.ejmech.2013.03.026
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Goswami, T. K., Gadadhar, S., Roy, M., Nethaji, M., Karande, A. A., & Chakravarty, A. R. (2012). Ferrocene-conjugated copper(II) complexes of l -methionine and phenanthroline bases: Synthesis, structure, and photocytotoxic activity. Organometallics, 31(8), 3010–3021. https://doi.org/10.1021/om201102k
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Maity, B., Gadadhar, S., Goswami, T. K., Karande, A. A., & Chakravarty, A. R. (2012). Photo-induced anticancer activity of polypyridyl platinum(II) complexes. European Journal of Medicinal Chemistry, 57, 250–258. https://doi.org/10.1016/j.ejmech.2012.09.025
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Hussain, A., Gadadhar, S., Goswami, T. K., Karande, A. A., & Chakravarty, A. R. (2012). Photo-induced DNA cleavage activity and remarkable photocytotoxicity of lanthanide(iii) complexes of a polypyridyl ligand. Dalton Transactions, 41(3), 885–895. https://doi.org/10.1039/c1dt11400j
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Hussain, A., Gadadhar, S., Goswami, T. K., Karande, A. A., & Chakravarty, A. R. (2012). Photoactivated DNA cleavage and anticancer activity of pyrenyl-terpyridine lanthanide complexes. European Journal of Medicinal Chemistry, 50, 319–331. https://doi.org/10.1016/j.ejmech.2012.02.011
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Maity, B., Gadadhar, S., Goswami, T. K., Karande, A. A., & Chakravarty, A. R. (2011). Impact of metal on the DNA photocleavage activity and cytotoxicity of ferrocenyl terpyridine 3d metal complexes. Dalton Transactions, 40(44), 11904–11913. https://doi.org/10.1039/c1dt11102g
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Bora, N., Gadadhar, S., & Karande, A. A. (2010). Signaling different pathways of cell death: Abrin induced programmed necrosis in U266B1 cells. International Journal of Biochemistry and Cell Biology, 42(12), 1993–2003. https://doi.org/10.1016/j.biocel.2010.08.012